Loading Zune Software in Vista. Error all the time..

I can't get Zune software to load on Vista, I have read all the tricks and
tips and no luck. I read one article and I was able to get the Zune software
of the disk but then it would never take the Windows updates for it. I tried
loading from Zune and using Admin priv and Compatabilty to XP. Still nothing.
I read the Zune will not load on NTFS drive which I have is that true? Anyone
else have an issue?
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PPHT