Getting Affinity/Priority to stick.

I have a program that Vista only wantos to run on one core. I have to
manually go in and set the afinity and priority everytime that I start the
program. I have to run it in XP compatibility mode. I was wondering if anyone
knows of a way to assign the affinity and priority so that it will stick to
the application. I want it to run on all four cores with realtime priority.
Any ideas would be appreciated.

Thanks