Is Bootability from USB Stick an USB Stick feature or motherboard dependent or both ? Detecting with software tool possible ?

If I want to boot from USB Stick:

Is this feature dependent from the USB sticks hardware internals or
from the motherboards hardware features or from both ?

Is there a software tool which can show me if all requirements for booting from USB stick are
given or is this only possible by reading the USB Stick/motherboard manual(s) ?

Joe